Familial Aggregation of Environmental Risk Factors and Familial Aggregation of Disease
نویسندگان
چکیده
منابع مشابه
Familial aggregation of environmental risk factors and familial aggregation of disease.
Almost all human diseases have been shown to aggregate familially to some degree. This familiality is generally taken as evidence for the existence of a genetic etiologic mechanism or environmental factors common to family members, or a combination of both. It has been argued that for a disease with strong familial aggregation, environmental risk factors alone are unlikely to account for such s...
متن کاملRe: "Control for environmental risk factors in assessing genetic effects on disease familial aggregation".
A probabilistic model was developed to assess the impact of two independent dichotomous familial risk factors on familial aggregation of a disorder in pairs of relatives where one member was ascertained as a proband or index subject (i.e., a case or control). Under this model, one risk factor is of primary interest (i.e., a susceptibility gene), while the effect of the other is to be controlled...
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Stroke is the second leading cause of death worldwide, and the leading cause of acquired disability in adults in most regions. Fifteen million people worldwide suffer a stroke each year with devastating effects; one third of these individuals die and another one third remains permanently disabled. However, there is a considerable additional unreported asymptomatic cerebrovascular disease. Accor...
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BACKGROUND The role of genetics in early-onset Parkinson's disease has been established, but whether there is a genetic contribution to the more common, late-onset form remains uncertain. METHODS We reviewed the medical records and confirmed the diagnosis of Parkinson's disease in 772 living and deceased patients in whom the disease had been diagnosed during the previous 50 years in Iceland. ...
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Objective: To describe clustering of death from Parkinson disease (PD) in relatives in a large US study. Methods: We analyzed the Utah Population Database resource, which includes genealogy data of more than 2.7 million individuals linked to 519,061 individuals with a Utah death certificate (DC). We identified individuals whose DC included PD as a cause of death using ICD coding. In those indiv...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2000
ISSN: 0002-9262,1476-6256
DOI: 10.1093/oxfordjournals.aje.a010156